Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness

doi:10.1038/s41598-017-07950-x

Эндаумент фонд ТГУ!
Впиши своё имя в историю университета
- Сделать пожертвование -

Szyf, M.

Add to "Quick Collection"

Description	Size	Format
Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness	1 MB	Adobe Acrobat PDF	Read	Download
DOI Доступ к ресурсу на сайте издателя			10.1038/s41598-017-07950-x

#тревожность

#раннее детство

#психические расстройства

#метилирование дезоксирибонуклеиновой кислоты

#молекулярные механизмы

Title: Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness
Creator: Gouin, J. P.
|
Booij, Linda
|
Boivin, Michel
|
Côté, Sylvana M.
|
Hébert, M.
|
Ouellet-Morin, Isabelle
|
Szyf, M.
|
Tremblay, Richard E.
|
Turecki, Gustavo
|
Zhou, Q. Q.
|
Vitaro, Frank
Date: 2017
DOI: 10.1038/s41598-017-07950-x
Description: Recent models propose deoxyribonucleic acid methylation of key neuro-regulatory genes as a molecular mechanism underlying the increased risk of mental disorder associated with early life adversity (ELA). The goal of this study was to examine the association of ELA with oxytocin receptor gene (OXTR) methylation among young adults. Drawing from a 21-year longitudinal cohort, we compared adulthood OXTR methylation frequency of 46 adults (23 males and 23 females) selected for high or low ELA exposure based on childhood socioeconomic status and exposure to physical and sexual abuse during childhood and adolescence. Associations between OXTR methylation and teacher-rated childhood trajectories of anxiousness were also assessed. ELA exposure was associated with one significant CpG site in the first intron among females, but not among males. Similarly, childhood trajectories of anxiousness were related to one significant CpG site within the promoter region among females, but not among males. This study suggests that females might be more sensitive to the impact of ELA on OXTR methylation than males.

Relationships: Show Relationship Browser for this Object
collection(s): Факультет психологии
Identifier: смотреть в электронном каталоге НБ ТГУ
Type: статьи в журналах
Source: Scientific Reports [Еlectronic resource]. 2017. Vol. 7. P. 7446 (1-14)
Language: eng

Created: 08-02-2018

3675 Visitors

3414 Hits

285 Downloads

Факультет психологии Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness