Global hypomyelination of the brain white and gray matter in schizophrenia: quantitative imaging using macromolecular proton fraction

doi:10.1038/s41398-021-01475-8

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Global hypomyelination of the brain white and gray matter in schizophrenia: quantitative imaging using macromolecular proton fraction	1015 KB	Adobe Acrobat PDF	Read	Download
DOI Доступ к ресурсу на сайте издателя			10.1038/s41398-021-01475-8

#гипомиелинизация

#шизофрения

#белое вещество головного мозга

#серое вещество головного мозга

#миелин

#макромолекулярная протонная фракция

Title: Global hypomyelination of the brain white and gray matter in schizophrenia: quantitative imaging using macromolecular proton fraction
Creator: Smirnova, Liudmila P.
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Yarnykh, Vasily L.
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Parshukova, Daria A.
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Kornetova, Elena G.
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Semke, Arkadiy V.
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Usova, Anna V.
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Pishchelko, Anna O.
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Khodanovich, Marina Yu.
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Ivanova, Svetlana A.
Date: 2021
DOI: 10.1038/s41398-021-01475-8
Description: Myelin deficiency is commonly recognized as an important pathological feature of brain tissues in schizophrenia (SZ). In this pilot study, global myelin content abnormalities in white matter (WM) and gray matter (GM) of SZ patients were non-invasively investigated using a novel clinically-targeted quantitative myelin imaging technique, fast macromolecular proton fraction (MPF) mapping. MPF maps were obtained from 23 healthy subjects and 31 SZ patients using a clinical 1.5T magnetic resonance imaging (MRI) scanner. Mean MPF in WM and GM was compared between the healthy control subjects and SZ patients with positive and negative leading symptoms using the multivariate analysis of covariance. The SZ patients had significantly reduced MPF in GM (p < 0.001) and WM (p = 0.02) with the corresponding relative decrease of 5% and 3%, respectively. The effect sizes for the myelin content loss in SZ relative to the control group were 1.0 and 1.5 for WM and GM, respectively. The SZ patients with leading negative symptoms had significantly lower MPF in GM (p < 0.001) and WM (p = 0.003) as compared to the controls and showed a significant MPF decrease in WM (p = 0.03) relative to the patients with leading positive symptoms. MPF in WM significantly negatively correlated with the disease duration in SZ patients (Pearson’s r = −0.51; p = 0.004). This study demonstrates that chronic SZ is characterized by global microscopic brain hypomyelination of both WM and GM, which is associated with the disease duration and negative symptoms. Myelin deficiency in SZ can be detected and quantified by the fast MPF mapping method.

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collection(s): НИИ биологии и биофизики
Identifier: смотреть в электронном каталоге НБ ТГУ
Type: статьи в журналах
Source: Translational psychiatry. 2021. Vol. 11. P. 365 (1-7)
Language: eng

Created: 23-05-2022

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НИИ биологии и биофизики Global hypomyelination of the brain white and gray matter in schizophrenia: quantitative imaging using macromolecular proton fraction