Quantitative assessment of low-dose photodynamic therapy effects on diabetic wound healing using Raman spectroscopy

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Quantitative assessment of low-dose photodynamic therapy effects on diabetic wound healing using Raman spectroscopy	14 MB	Adobe Acrobat PDF	Read	Download
DOI Доступ к ресурсу на сайте издателя			10.3390/pharmaceutics15020595

Title: Quantitative assessment of low-dose photodynamic therapy effects on diabetic wound healing using Raman spectroscopy
Creator: Zuhayri, Hala
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Samarinova, Alisa A.
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Borisov, Alexey V.
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Lopez Guardado, David A.
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Baalbaki, Houssain A.
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Krivova, Natalya A.
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Kistenev, Yury V.
Date: 2023
DOI: 10.3390/pharmaceutics15020595
Description: One of challenges that faces diabetes is the wound healing process. The delayed diabetic wound healing is caused by a complicated molecular mechanism involving numerous physiological variables. Low-dose photodynamic therapy (LDPDT) provides excellent results in rejuvenation and wound healing. In this study, the LDPDT effect on diabetic wounds in mice was studied using two photosensitizers, 5-aminolevulinic acid and methylene blue, and two laser dose expositions of 1 J/cm2 and 4 J/cm2 by Raman spectroscopy (RS). The latter was used as a noninvasive method, providing specific information about tissue state based on the fundamental vibrational modes of its molecular components. RS allows high spatial resolution acquisition of biochemical and structural information through the generation of point spectra or spectral images. An approach to in vivo quantitative assessment of diabetic wound healing state was developed. This approach is based on an application of the principal component analysis combined with the Mahalanobis metrics to skin Raman spectra, in particular, intensities of the amide I and CH2 bands.

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collection(s): Институт биологии, экологии, почвоведения, сельского и лесного хозяйства (Биологический институт) | Факультет инновационных технологий | Физический факультет | Научное управление
Identifier: смотреть в электронном каталоге НБ ТГУ
Type: статьи в журналах
Source: Pharmaceutics. 2023. Vol. 15, № 2. P. 595 (1-22)
Language: eng

Created: 09-01-2024

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