Immunotoxicity study of cucurbit[n]urils (n = 6, 7, 8) and modeling of interaction with some monocyte receptors by a molecular docking method

doi:10.3390/molecules30102249

Эндаумент фонд ТГУ!
Впиши своё имя в историю университета
- Сделать пожертвование -

Add to "Quick Collection"

Description	Size	Format
Immunotoxicity study of cucurbit[n]urils (n = 6, 7, 8) and modeling of interaction with some monocyte receptors by a molecular docking method	4 MB	Adobe Acrobat PDF	Read	Download
DOI Доступ к ресурсу на сайте издателя			10.3390/molecules30102249

#толл-подобные рецепторы

Title: Immunotoxicity study of cucurbit[n]urils (n = 6, 7, 8) and modeling of interaction with some monocyte receptors by a molecular docking method
Creator: Zhautikova, Saule B.
|
Abdykhanova, Nursipat N.
|
Fedorishin, Dmitriy A.
|
Shapovalova, Yelena G.
|
Khlebnikov, Andrei I.
|
Bakibaev, Abdigali A.
|
Kurzina, Irina A.
|
Kabieva, Saule K.
|
Boranbay, Nazerke
|
Zhumanazarova, Gaziza M.
Date: 2025
DOI: 10.3390/molecules30102249
Description: n this study, cucurbit[n]urils (n = 6, 7, 8) were carefully evaluated for their cytotoxicity and immunotoxicity to human peripheral blood monocytes. The cytotoxicity was studied by evaluating the survival of monocytes, while the immunotoxicity level was assessed by analyzing the inflammatory mediators secreted by them using an enzyme-linked immunosorbent assay. It was found that cucurbit[n]urils (n = 6, 7, 8) in the used concentration (10−5 M) do not cause a negative effect on cell viability, which is maintained at a level above 50%. At the same time, cucurbit[n]urils (n = 6, 7, 8) do not cause pro-inflammatory activation of monocytic macrophages. The absence of stimulation of pro-inflammatory cytokine expression demonstrates the promising biocompatibility of the studied compounds, which is crucial for their successful clinical use. The obtained results of molecular modeling show the possibility of formation of CB[6], CB[7], and CB[8] associates with various Toll-like receptors, which also confirms good prospects for the development of new ways of medical application of cucurbit[n]urils.

Relationships: Show Relationship Browser for this Object
collection(s): Химический факультет
Identifier: смотреть в электронном каталоге НБ ТГУ
Relation: Molecules
Type: статьи в журналах
Source: Molecules. 2025. Vol. 30, № 10. P. 2249 (1-19)
Language: eng

Created: 27-10-2025

72 Visitors

72 Hits

9 Downloads

Химический факультет Immunotoxicity study of cucurbit[n]urils (n = 6, 7, 8) and modeling of interaction with some monocyte receptors by a molecular docking method