MR histology of advanced atherosclerotic lesions of ApoE- knockout mice

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MR histology of advanced atherosclerotic lesions of ApoE- knockout mice	731 KB	Adobe Acrobat PDF	Read	Download
DOI Доступ к ресурсу на сайте издателя			10.1088/1742-6596/677/1/012008

Title: MR histology of advanced atherosclerotic lesions of ApoE- knockout mice
Creator: Naumova, Anna V.
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Ferguson, M.
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Rosenfeld, M.
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Yuan, C.
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Yarnykh, Vasily L.
Date: 2016
DOI: 10.1088/1742-6596/677/1/012008
Description: The purposes of this study were to examine the feasibility of determining the composition of advanced atherosclerotic plaques in fixed ApoE-knockout mice and to develop a time-efficient microimaging protocol for MR histological imaging on mice. Five formalin-fixed transgenic ApoE-knockout mice were imaged at the 9.4T Bruker BioSpec MR scanner using 3D spoiled gradient-echo sequence with an isotropic field of view of 24 mm3; TR 20.8 ms; TE 2.6 ms; flip angle 20°, resulted voxel size 47 × 63 × 94 pm3. MRI examination has shown that advanced atherosclerotic lesions of aorta, innominate and carotid arteries in ApoE-knockout mice are characterized by high calcification and presence of the large fibrofatty nodules. MRI quantification of atherosclerotic lesion components corresponded to histological assessment of plaque composition with a correlation coefficient of 0.98.

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collection(s): Институт биологии, экологии, почвоведения, сельского и лесного хозяйства (Биологический институт) | НИИ биологии и биофизики
Identifier: смотреть в электронном каталоге НБ ТГУ
Type: статьи в журналах
Source: Journal of Physics: Conference Series. 2016. Vol. 677. P. 012008 (1-3)
Language: eng

Created: 12-04-2018

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