Reprogrammed CD8+ T-lymphocytes isolated from bone marrow have anticancer potential in lung cancer

doi:10.3390/biomedicines10061450

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DOI Доступ к ресурсу на сайте издателя			10.3390/biomedicines10061450

#Льюиса карцинома легкого

#иммунотерапия рака

#MEK-ингибиторы

Title: Reprogrammed CD8+ T-lymphocytes isolated from bone marrow have anticancer potential in lung cancer
Creator: Skurikhin, Evgenii G.
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Pershina, Olga
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Ermakova, Natalia N.
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Pakhomova, Angelina
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Widera, Darius
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Zhukova, Mariia
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Pan, Edgar S.
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Sandrikina, Lubov
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Kogai, Lena
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Kushlinskii, Nikolai
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Morozov, Sergey G.
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Kubatiev, Aslan A.
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Dygai, Alexander M.
Date: 2022
DOI: 10.3390/biomedicines10061450
Description: CD8+ T-lymphocytes play a key role in antitumor immune response. Patients with lung cancer often suffer from T-lymphocyte dysfunction and low T-cell counts. The exhaustion of effector T-lymphocytes largely limits the effectiveness of therapy. In this study, reprogrammed T-lymphocytes used MEK inhibitors and PD-1 blockers to increase their antitumor activity. Antitumor effects of reprogrammed T-lymphocytes were shown in vitro and in vivo in the Lewis lung carcinoma model. The population of T- lymphocytes with persistent expression of CCR7 was formed as a result of reprogramming. Reprogrammed T-lymphocytes were resistant to apoptosis and characterized by high cytotoxicity against Lewis lung carcinoma (LLC) cells in vitro. Administration of reprogrammed T-lymphocytes to C57BL/6 mice with LLC reduced the number of lung metastases. The antitumor effect resulted from the elimination of tumor cells and cancer stem cells, and the effect of therapy on cytotoxic T-lymphocyte counts. Thus, reprogramming of T-lymphocytes using MEK inhibitors is a promising approach for targeted therapy of lung cancer.

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collection(s): Физический факультет
Identifier: смотреть в электронном каталоге НБ ТГУ
Type: статьи в журналах
Source: Biomedicines. 2022. Vol. 10, № 6. P. 1450 (1-18)
Language: eng

Created: 16-11-2022

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Физический факультет Reprogrammed CD8+ T-lymphocytes isolated from bone marrow have anticancer potential in lung cancer