Authors: Skurikhin, Evgenii G. | Pershina, Olga | Ermakova, Natalia N. | Pakhomova, Angelina | Zhukova, Mariia | Pan, Edgar S. | Sandrikina, Lubov | Widera, Darius | Kogai, Lena | Kushlinskii, Nikolai | Kubatiev, Aslan A. | Morozov, Sergey G. | Dygai, Alexander M.

Source: International journal of molecular sciences. 2022. Vol. 23, № 24. P. 15780 (1-16)

Type: статьи в журналах

Date: 2022

Description: Using a model of Lewis lung carcinoma (LLC) in vitro and in vivo, we previously demonstrated increased antitumor activity in CD8+ T-cells reprogrammed with an MEK inhibitor and PD-1 blocker. In this f ... More

Authors: Skurikhin, Evgenii G. | Pershina, Olga | Ermakova, Natalia N. | Pakhomova, Angelina | Widera, Darius | Zhukova, Mariia | Pan, Edgar S. | Sandrikina, Lubov | Kogai, Lena | Kushlinskii, Nikolai | Morozov, Sergey G. | Kubatiev, Aslan A. | Dygai, Alexander M.

Source: Biomedicines. 2022. Vol. 10, № 6. P. 1450 (1-18)

Type: статьи в журналах

Date: 2022

Description: CD8+ T-lymphocytes play a key role in antitumor immune response. Patients with lung cancer often suffer from T-lymphocyte dysfunction and low T-cell counts. The exhaustion of effector T-lymphocytes la ... More

Authors: Bychkov, Vyacheslav A. | Pevzner, A. M. | Nebova, J. A. | Ermakova, Natalia N. | Ibragimova, Marina K. | Tsyganov, Matvey M. | Lyapunova, L. S. | Litvyakov, Nicolay V.

Source: Experimental oncology. 2021. Vol. 43, № 2. P. 118-124

Type: статьи в журналах

Date: 2021

Description: In the setting of limited resources, natural selection begins to occur between tumor clones. An experimental model of in vitro tumor heterogeneity would allow us to evaluate various types of biologica ... More