This work suggests a new general synthetic methodology combining organofluorine and heterocyclic chemistry. The methodology is exemplified with n-6 and angular and linear n6-n’ (n, n’=5, 6, 7) scaffolds, including hybrids (n ¼6 n’), and such heterocyclic moieties as 1,3-diazoles, 1,2,3-triazoles, 1,2,5- thia(selena)diazoles, 1,4-diazines and 1,5-diazepines. It easily expands beyond diaza-heterocyclic chemistry as shown with 1,2,5-thiadiazole/1,3,2-dioxaborole hybrid. Chemically, the methodology is economic and unified as it is based on the only starting material 1 and a very limited number of simple substitution and condensation reactions. Specific compounds prepared in this work are of biomedical interest in the context of apoptotic anticancer activity and, with dioxaborole ring, radiation therapy of cancer. New 1,2,5- chalcogenadiazoles are protected forms of otherwise hardly accessible fluorine-containing di- and tetra-amines for further syntheses
Химический факультет
Научное управление
Fluorine-containing n-6 and angular and linear n-6-n’ (n, n’=5, 6, 7) diaza-heterocyclic scaffolds assembled on benzene core in unified way