https://vital.lib.tsu.ru/vital/access/manager/Index ${session.getAttribute("locale")} 5 https://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001000863 -3.0 or <= -3.0 mL/min/1.73 m(2)/year, respectively. Fifty-five urinary metabolites and ratios were quantified, and the significant ones were selected. Logistic regression was used to determine prognostic performance in identifying those with a fast progressive course using baseline urine samples. Repeated-measures ANOVA was used to analyze whether changes in urinary metabolites over a 3-year follow-up period differed between fast and slow progressors. Results: In a single urinary sample, the prognostic performance of urinary metabolites was comparable to that of a model including height-adjusted total kidney volume (htTKV, AUC = 0.67). Combined with htTKV, the predictive value of the metabolite model increased (AUC = 0.75). Longitudinal analyses showed an increase in the myoinositol/citrate ratio (p < 0.001) in fast progressors, while no significant change was found in those with slow progression, which is in-line with an overall increase in the myoinositol/citrate ratio as GFR declines. Conclusion: A metabolic profile, measured at a single time point, showed at least equivalent prognostic performance to an imaging-based risk marker in ADPKD. Changes in urinary metabolites over a 3-year follow-up period were associated with a fast progressive disease course.]]> Wed 10 May 2023 10:12:38 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000575397 Wed 10 May 2017 10:41:33 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000514578 Thu 19 Oct 2017 13:17:29 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000620546 Mon 19 Feb 2018 09:50:32 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/koha:000901389 Mon 17 Oct 2022 14:24:12 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000500436 Mon 03 Dec 2018 10:45:39 KRAT ]]>