https://vital.lib.tsu.ru/vital/access/manager/Index ${session.getAttribute("locale")} 5 https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000629816 A, c.366T>A, c.4357+2T>A) were found in position of previously described polymorphisms in dbSNPs: rs80357544 (c.321delT), rs190900046 (c.366T>G), and rs80358152 (c.4357+2T>C), respectively. Other three new sequence variants (c.3605A>G, c.1998A>C, and c.80+13A>C) have not been previously described in dbSNP, BIC and Human Gene Mutation Databases. CONCLUSIONS: We described six new sequence variants that have never been published in the literature or databases. Further studies are required to confirm the impact of new sequence variants on the risk of breast cancer in the Buryat Mongol population.]]> Wed 27 Jun 2018 09:40:18 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000629818 Wed 27 Jun 2018 09:40:13 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000629819 Wed 27 Jun 2018 09:40:12 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000645263 0.05, respectively). These results suggest a need for the further investigation of dynamic changes in levels of LINE-1 methylation depending on the antitumor therapy.]]> Wed 19 Dec 2018 14:12:43 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000645262 G) were similar in healthy Siberian women (n = 136) and cancer patients (n = 129) (A0,73:G0,27) and intermediate between the European and Asian populations, while genotype distributions were different, with the increase of AG rate in breast cancer patients (OR = 1.76; 95% CI = 1.04–1.90; P(Y) = 0.035 χ2 = 4.44). Heterozygous AG genotype was associated with tumour size (OR = 3.67, P(Y) = 0.004), ER-negative tumours (OR = 3.25, P(Y) = 0.0028), triple-negative tumours (OR = 4.94, P(Y) = 0.015) but not menopausal status, PR and HER-2 status, local or distant metastasis. Homozygous GLCE genotypes (AA/GG) were more common for ER + PR + luminal A breast cancer (OR = 0.25, P(Y) = 0.031). Loss-of-heterozigosity was identified in 5 of 51 breast tumours and the loss of G allele was associated with the decreased GLCE expression. Epidemiologic data for the GLCE SNP in different racial/ethnic groups demonstrated high AG genotype rates as a risk factor not for breast cancer incidence but for poor prognosis of the disease. The obtained data suggest an involvement of GLCE rs3865014 in breast cancer development. Heterozygous AG genotype might be a risk factor for breast cancer susceptibility in Siberian women and is associated with aggressive ER-negative and triple-negative cancer subtypes.]]> Wed 19 Dec 2018 14:12:22 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000644448 Wed 05 Dec 2018 13:03:11 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000644447 Wed 05 Dec 2018 13:03:07 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000644369 Wed 05 Dec 2018 12:35:57 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000644368 Wed 05 Dec 2018 12:28:44 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000615946 Tue 28 Nov 2017 10:35:21 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000615997 Tue 28 Nov 2017 10:34:59 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000645063 Tue 18 Dec 2018 09:36:53 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000556341 Thu 16 Feb 2017 10:23:03 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000621056 Mon 26 Feb 2018 16:15:50 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000632341 Mon 01 Oct 2018 10:36:45 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000632338 Mon 01 Oct 2018 10:36:40 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000632337 Mon 01 Oct 2018 10:36:34 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000632340 Mon 01 Oct 2018 10:36:32 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000632335 Mon 01 Oct 2018 10:29:53 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000632336 Mon 01 Oct 2018 10:29:42 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000632275 Mon 01 Oct 2018 09:26:37 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000644979 Fri 14 Dec 2018 10:52:59 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000633342 Fri 05 Oct 2018 10:01:07 KRAT ]]>