https://vital.lib.tsu.ru/vital/access/manager/Index ${session.getAttribute("locale")} 5 https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000629816 A, c.366T>A, c.4357+2T>A) were found in position of previously described polymorphisms in dbSNPs: rs80357544 (c.321delT), rs190900046 (c.366T>G), and rs80358152 (c.4357+2T>C), respectively. Other three new sequence variants (c.3605A>G, c.1998A>C, and c.80+13A>C) have not been previously described in dbSNP, BIC and Human Gene Mutation Databases. CONCLUSIONS: We described six new sequence variants that have never been published in the literature or databases. Further studies are required to confirm the impact of new sequence variants on the risk of breast cancer in the Buryat Mongol population.]]> Wed 27 Jun 2018 09:40:18 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000629819 Wed 27 Jun 2018 09:40:12 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000662056 Wed 25 Sep 2019 11:02:45 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000662060 Wed 25 Sep 2019 11:02:29 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000662003 Wed 25 Sep 2019 09:59:38 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001133259 Wed 24 Apr 2024 10:21:19 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/koha:000925698 Wed 21 Dec 2022 15:18:36 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000645262 G) were similar in healthy Siberian women (n = 136) and cancer patients (n = 129) (A0,73:G0,27) and intermediate between the European and Asian populations, while genotype distributions were different, with the increase of AG rate in breast cancer patients (OR = 1.76; 95% CI = 1.04–1.90; P(Y) = 0.035 χ2 = 4.44). Heterozygous AG genotype was associated with tumour size (OR = 3.67, P(Y) = 0.004), ER-negative tumours (OR = 3.25, P(Y) = 0.0028), triple-negative tumours (OR = 4.94, P(Y) = 0.015) but not menopausal status, PR and HER-2 status, local or distant metastasis. Homozygous GLCE genotypes (AA/GG) were more common for ER + PR + luminal A breast cancer (OR = 0.25, P(Y) = 0.031). Loss-of-heterozigosity was identified in 5 of 51 breast tumours and the loss of G allele was associated with the decreased GLCE expression. Epidemiologic data for the GLCE SNP in different racial/ethnic groups demonstrated high AG genotype rates as a risk factor not for breast cancer incidence but for poor prognosis of the disease. The obtained data suggest an involvement of GLCE rs3865014 in breast cancer development. Heterozygous AG genotype might be a risk factor for breast cancer susceptibility in Siberian women and is associated with aggressive ER-negative and triple-negative cancer subtypes.]]> Wed 19 Dec 2018 14:12:22 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000644448 Wed 05 Dec 2018 13:03:11 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000644369 Wed 05 Dec 2018 12:35:57 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000644368 Wed 05 Dec 2018 12:28:44 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000615997 Tue 28 Nov 2017 10:34:59 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000578012 Tue 27 Jun 2017 12:26:41 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000577910 Tue 27 Jun 2017 10:34:44 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000577856 Tue 27 Jun 2017 10:27:47 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000577877 Tue 27 Jun 2017 10:27:39 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000645063 Tue 18 Dec 2018 09:36:53 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000534175 Tue 11 Dec 2018 09:45:30 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000651571 C (rs2071559) and KDR 1192G>A (rs2305948) polymorphisms. The pCR was used as an end-point in the treatment efficacy analysis. In the univariate analysis, the pCR rate was strongly associated with young age (P = 0.004), high Ki67 expression (P = 0.012), lymph node negativity (P = 0.023) as well as with positive VEGFR2 expression (P = 0.019) and the CAX regimen (P = 0.005). In the multivariate analysis, only patient’s age (P = 0.005) and pre-NCT VEGFR2 expression (P = 0.048) remained significant predictors of pCR. The pCR rate was higher in the CAX-treated patients than that in the FAC-treated patients (P = 0.005). Our results revealed that − 604TT genotype of rs2071559 and age < 50 years were correlated with a pCR in the CAX-treated patients. VEGFR2 expression in pre-NCT tumors and KDR gene polymorphism can be considered as additional predictive molecular markers of pCR in Russian TN breast cancer patients treated with NCT.]]> Tue 09 Apr 2019 14:51:05 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000651305 Tue 07 May 2019 10:55:13 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/koha:000902491 Tue 01 Nov 2022 13:37:01 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000581436 Thu 28 Sep 2017 16:26:10 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000652073 Thu 18 Apr 2019 10:49:56 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000556341 Thu 16 Feb 2017 10:23:03 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000486173 Thu 13 Dec 2018 10:22:55 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000577655 Sat 29 Jul 2017 18:30:37 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000577681 Sat 29 Jul 2017 18:30:36 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000621056 Mon 26 Feb 2018 16:15:50 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001003659 Mon 19 Jun 2023 16:12:46 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000553236 Mon 03 Dec 2018 09:35:44 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000632341 Mon 01 Oct 2018 10:36:45 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000632337 Mon 01 Oct 2018 10:36:34 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000632335 Mon 01 Oct 2018 10:29:53 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000632336 Mon 01 Oct 2018 10:29:42 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000648502 Fri 29 Mar 2019 19:25:21 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000634057 Fri 19 Oct 2018 16:10:00 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001015783 T) was identified in two unrelated patients with a family history of cancer (7.6%, 2/26). The pathogenic truncating variant in the ATM gene (p. R805* or c.2413C > T) leads to the nonfunctional version of the protein. This variant has been earlier reported in individuals with a family history of breast cancer. Conclusions Our pilot study describes the germline variant in the ATM gene associated with breast cancer in Khakass women of North Asia.]]> Fri 15 Dec 2023 13:26:29 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/koha:000902818 Fri 11 Nov 2022 11:43:10 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000633342 Fri 05 Oct 2018 10:01:07 KRAT ]]>