https://vital.lib.tsu.ru/vital/access/manager/Index ${session.getAttribute("locale")} 5 Exploration of nitrogen heterocycle scaffolds for the development of potent human neutrophil elastase inhibitors https://vital.lib.tsu.ru/vital/access/manager/Repository/koha:000923734 6 h). Molecular modeling studies demonstrated that inhibitory activity was strictly dependent on the formation of a Michaelis complex between the OH group of HNE Ser195 and the carbonyl carbon of the inhibitor. Moreover, in silico ADMET calculations predicted that most of the new compounds would be optimally absorbed, distributed, metabolized, and excreted. Thus, these new and potent HNE inhibitors represent novel leads for future therapeutic development.]]> Tue 29 Nov 2022 14:42:11 KRAT ]]> Cardioprotective effects of a selective c-Jun N-terminal kinase inhibitor in a rat model of myocardial infarction https://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001132677 Tue 09 Apr 2024 15:17:34 KRAT ]]> Neuroprotective effects of the lithium salt of a novel JNK inhibitor in an animal model of cerebral ischemia-reperfusion https://vital.lib.tsu.ru/vital/access/manager/Repository/koha:000999967 Thu 20 Apr 2023 09:07:25 KRAT ]]>