https://vital.lib.tsu.ru/vital/access/manager/Index ${session.getAttribute("locale")} 5 https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000662005 Wed 25 Sep 2019 09:59:29 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/koha:000894536 Wed 25 May 2022 13:19:30 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000579964 Wed 23 Aug 2017 09:32:51 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000645258 Wed 19 Dec 2018 14:12:38 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000644370 Wed 05 Dec 2018 12:35:56 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/koha:000703217 Tue 28 Sep 2021 12:47:13 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000577687 Tue 27 Jun 2017 10:34:38 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000648508 Tue 19 Feb 2019 10:59:53 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/koha:000722281 A), F5 (1691 G> A), F7 (10976G> A), F13 163 G> T), F1 (-455G> A), GP Ia-IIa (807C> T), GP IIb-IIIa (1565 T> C), PAI-I (-675 5G> 4G).The genotypes were determined by polymerase chain reaction methods. Results: Among 913 patients who were hospitalized with ACS, 44 (4.8%) had NOCA. Including 19 men (66%) and 25 (57%) women, the average age of patients was 54 ± 11 years. Among 29 patients in 28 (96.6%) individuals with NOCA had at least one homozygous or heterozygous for unfavorable alleles genotype of haemostatic system. The homozygous genotype for adverse allelic variants was registered in 13 (44.8%) patients by polymorphic variants of the following genes: FXIII, GP Ia-IIa, GP IIb-IIIa, PAI-1, including 2 unfavorable homozygous genotype for variants of GP IIb-IIIa and PAI-1 genes. One patient (3.4%) had unfavorable heterozygous genotypes according to 5 studied variants predisposing to the development of thrombophilia; seven (24.1%) have heterozygous genotypes of 4 SNP, ten (34.5%) have heterozygous genotypes of 3 SNP, seven (24.1%) have 2 SNPs, two (6.9%) - 2 SNP each; Only two (6.9%) individuals did not have adverse alleles in the heterozygous state. The frequency of registration of homozygous genotypes for alleles predisposing to thromboses for all the studied polymorphic variants in the survey sample is within the limits shown for the european population, and the frequency of heterozygotes registration for variants of the FV, FVII, FXIII, FI gene, it exceeds estimates of heterozygotes prevalence in european population. Conclusion: The proportion of patients with NOCA among patients with ACS in 2015-2016 was 4.8%. The prevalence of adverse allelic variants of clotting factor genes associated with risk of thrombophilia in patients with ACS and NOCA was 96.6%]]> Tue 14 Dec 2021 01:02:38 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000500271 Tue 04 Dec 2018 10:12:39 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001002892 Thu 22 Jun 2023 05:25:37 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000578439 Mon 21 Aug 2017 11:06:17 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000578440 Mon 21 Aug 2017 11:06:17 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000578436 Mon 21 Aug 2017 11:06:16 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/koha:000722064 Mon 13 Dec 2021 16:42:12 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000500435 Mon 03 Dec 2018 10:17:54 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001001435 Fri 19 May 2023 14:48:00 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/koha:000924834 Fri 09 Dec 2022 15:46:23 KRAT ]]>