A case of xenon inhalation therapy for respiratory failure and neuropsychiatric disorders associated with COVID-19

doi:10.17179/excli2021-4316

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дыхательная недостаточность | Naumov, Sergei Sergeevich

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DOI Доступ к ресурсу на сайте издателя			10.17179/excli2021-4316

#COVID-19

#ксенон

#сурфактанты

#дыхательная недостаточность

#нервно-психические расстройства

#молекулярное моделирование

Title: A case of xenon inhalation therapy for respiratory failure and neuropsychiatric disorders associated with COVID-19
Creator: Udut, Vladimir V.
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Naumov, Sergei Alexandrovich
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Evtushenko, Diana Nikolaevna
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Udut, Elena V.
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Naumov, Sergei Sergeevich
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Zyuzkov, Gleb N.
Date: 2021
DOI: 10.17179/excli2021-4316
Description: Acute respiratory distress syndrome (ARDS) is the main danger to the life of patients with pneumonia caused by SARS-CoV-2. At the same time, respiratory failure (RF) after ARDS can persist for a long time despite intensive therapy. Therefore, it is important to develop new effective approaches for restoring the ventilation function of the lungs after COVID-19. Here, we present a case report of effective application of short-term inhalations of xenon-oxygen (Xe/O2) gas mixture for treatment of RF and neuropsychiatric disorders (NPD) associated with COVID-19. The patient inhaled a gas mixture of 70 % Xe and 30 % O2. We used multispiral computed tomog-raphy, evaluated psychometry, studied hematological and biochemical blood parameters, and applied some other methods of clinical studies to assess the therapeutic effectiveness of Xe inhalation. Also, we studied the mecha-nism of action of xenon with computer modeling. The clinical case showed the high efficacy of Xe/O2 mixture for treating severe RF and NPD after SARS-CoV-2 infection. Xenon inhalations dramatically increased oxygen saturation and the degree of pneumatization of the lungs. We found out that in coronavirus pneumonia, saturated phospholipids of surfactant are transferred to the solid-ordered phase, which disrupts the surface tension of the alveoli and alveolar gas exchange. Using molecular modeling methods, we demonstrated that the xenon atom in-creases the distance between the acyl chains of phospholipids due to the van der Waals dispersion interaction. These changes allow for the phase transition of phospholipids from the solid-ordered phase to the liquid phase and restore the functional activity of the surfactant. The findings suggest the feasibility of conducting studies on the effectiveness of Xe/O2 inhalations for treating ARDS in SARS-CoV-2 infection.