From cobalt(II), nickel(II) and copper(II) (2-thio)barbiturates to their imidazole-based complex salts: Synthesis, structure, physicochemical and biological properties

doi:10.1016/j.ica.2025.122643

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From cobalt(II), nickel(II) and copper(II) (2-thio)barbiturates to their imidazole-based complex salts: Synthesis, structure, physicochemical and biological properties	6 MB	Adobe Acrobat PDF	Read	Download
DOI Доступ к ресурсу на сайте издателя			10.1016/j.ica.2025.122643

#металлокомплексы

#барбитуровая кислота

#2-тиобарбитуровая кислота

#имидазол

#кристаллическая структура

#антибактериальная активность

#цитотоксичность

Title: From cobalt(II), nickel(II) and copper(II) (2-thio)barbiturates to their imidazole-based complex salts: Synthesis, structure, physicochemical and biological properties
Creator: Lakeev, Alexander P.
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Sukhikh, Taisiya S.
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Korzhova, Alena G.
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Rybalkina, Olga Yu.
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Buyko, Evgeny E.
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Korotchenko, Natalya M.
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Kurzina, Irina A.
Date: 2025
DOI: 10.1016/j.ica.2025.122643
Description: A series of metal(II) complexes based on 1,3-diazinane-2,4,6-trione (H2BA, C4H4N2O3) or 2-sulfanylidene-1,3-diazinane-4,6-dione (H2TBA, C4H4N2O2S) with the formula [M(H2O)4(HBA)2] (1, 2), [Cu(H2O)3(HBA)2] (3) and [M(H2O)2(HTBA)2] (4, 5) (M = Co, Ni) were synthesized. These compounds were then used to obtain novel complex salts [M(H2O)m(Im)n](H(T)BA)2 ⋅ pH2O (m = 0 or 2, n = 4 or 6, p = 0, 2 or 4) and [Cu(H2O)(Im)4] (HBA)2 ⋅ 3H2O, where Im is 1H-imidazole (C3H4N2). The isolated products were characterized using elemental analysis, FT-IR spectroscopy, XRD and TG–DSC. Complexes 1–5 were slightly soluble in water (–logKsp ranged from 5.10 for 5 to 7.45 for 4) and started to undergo oxidative degradation at 220–300 ◦C. The presence of [MH (T)BA]+ species in acidic solutions was revealed, and their β11 values, which varied within a range of ~2–3 log units, were determined using the solubility method and pH-metry. Metal(II) imidazole complexes, with some exceptions, were more soluble than 1–5, but their decomposition started to occur at 130–175 and 325–450 ◦C for the Im and H(T)BAˉ moieties, respectively. The preservation of their inner coordination sphere after dissolution in water was confirmed by UV–Vis spectroscopy. The spectra had typical λmax values for metal(II)–Im systems: ~500 nm (Co2+), ~632 nm (Ni2+) and ~631 nm (Cu2+). In the crystal structures of salts, 3D supramolecular frameworks were assembled by water molecules, complex cations and corresponding anions through hydrogen bonding. During biological testing, only nickel(II) imidazole complexes demonstrated enhanced bacteriostatic activity against E. coli. The cytotoxicity of copper-based compounds was significantly higher for SKOV3 cancer cells than against HepG2 cells.

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collection(s): Химический факультет
Identifier: смотреть в электронном каталоге НБ ТГУ
Relation: Inorganica chimica acta
Rights: Resource access is available in the premises of Research Library
Type: статьи в журналах
Source: Inorganica chimica acta. 2025. Vol. 582. P. 122643 (1-13)
Language: rus

Created: 05-11-2025

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Химический факультет From cobalt(II), nickel(II) and copper(II) (2-thio)barbiturates to their imidazole-based complex salts: Synthesis, structure, physicochemical and biological properties