Mitochondrial respiration inhibition after exposure to UWB pulses as a possible mechanism of antitumor action

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Mitochondrial respiration inhibition after exposure to UWB pulses as a possible mechanism of antitumor action	231 KB	Adobe Acrobat PDF	Read	Download
DOI Доступ к ресурсу на сайте издателя			10.1088/1742-6596/830/1/012010

Title: Mitochondrial respiration inhibition after exposure to UWB pulses as a possible mechanism of antitumor action
Creator: Romanchenko, Ilya V.
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Bolshakov, Mikhail A.
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Rostov, Vladislav V.
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Zharkova, L.
Date: 2017
DOI: 10.1088/1742-6596/830/1/012010
Description: The respiration of isolated mice liver mitochondria after exposure to nanosecond UWB pulses (0.15 – 36 kV/cm, 0.6 – 1.0 GHz centre frequency, 3 – 20 ns pulse duration) has been investigated. The respiratory control (RC, the ratio of oxygen consumption) was estimated. The possibility of mitochondrial membrane electroporation was detected as the decrease in the electrical resistance, according to the β-dispersion of the electric current. The monotonous decrease of RC after 1000 UWB pulses from 0.15 kV/cm was observed, the ohmic resistance of mitochondria suspension was reduced. The obtained data indicate the inhibitory effect of UWB pulses on a state of irradiated mitochondria and its membrane.