Confocal Raman microspectroscopy for evaluation of optical clearing efficiency of the skin ex vivo

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Confocal Raman microspectroscopy for evaluation of optical clearing efficiency of the skin ex vivo	316 KB	Adobe Acrobat PDF	Read	Download
DOI Доступ к ресурсу на сайте издателя			10.1117/12.2550352

Title: Confocal Raman microspectroscopy for evaluation of optical clearing efficiency of the skin ex vivo
Creator: Schleusener, Johannes
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Lademann, Jürgen
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Tuchin, Valery V.
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Darvin, Maxim E.
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Yanina, Irina Yu.
Date: 2020
DOI: 10.1117/12.2550352
Description: Optical clearing (OC) of biological t issues is a promising technology for a wide spread use in medical practice to increase the screening depth, spatial resolution and contrast of the resulting images /spectra. Nevertheless, despite the significant OC effect, some biocompatible optical clearing agents (OCAs) can adversely affect biological tissues, causing local hemostasis, morphological changes, d ehydration, and in some cases even tissue necrosis. The aim of this study was to study the effect of Omnipaque®300 and fructose solutions of various concentrations and exposure times on the intact skin using confocal Raman microspectroscopy. It was shown that the application of each of these OCAs on intact skin for 5 min also leads to an appreciable OC effect. The increase in OC was achieved using a mixture of Omnipaque®300 with DMSO; it was shown that the optical properties of the skin can be controlled at a depth of about 80 μm.

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collection(s): Научное управление
Identifier: смотреть в электронном каталоге НБ ТГУ
Type: статьи в журналах
Source: Proceedings of SPIE. 2020. Vol. 11239 : Dynamics and fluctuations in biomedical photonics XVII. P. 112390W-1-112390W-7
Language: eng

Created: 13-01-2021

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Научное управление Confocal Raman microspectroscopy for evaluation of optical clearing efficiency of the skin ex vivo