Pilot study of transcranial photobiomodulation of lymphatic clearance of beta-amyloid from the mouse brain: breakthrough strategies for non-pharmacologic therapy of Alzheimer's disease

doi:10.1364/BOE.10.004003

Эндаумент фонд ТГУ!
Впиши своё имя в историю университета
- Сделать пожертвование -

2019

Add to "Quick Collection"

Description	Size	Format
Pilot study of transcranial photobiomodulation of lymphatic clearance of beta-amyloid from the mouse brain: breakthrough strategies for nonpharmacologic therapy of Alzheimer	2 MB	Adobe Acrobat PDF	Read	Download
DOI Доступ к ресурсу на сайте издателя			10.1364/BOE.10.004003

#Альцгеймера болезнь

#транскраниальная фотобиомодуляция

#оптическая когерентная томография

Title: Pilot study of transcranial photobiomodulation of lymphatic clearance of beta-amyloid from the mouse brain: breakthrough strategies for non-pharmacologic therapy of Alzheimer's disease
Creator: Navolokin, Nikita A.
|
Shirokov, Alexander
|
Khlebtsov, Boris N.
|
Dubrovsky, Alexander
|
Saranceva, Elena
|
Abdurashitov, Arkady S.
|
Khorovodov, Alexander P.
|
Terskov, Andrey V.
|
Mamedova, Aysel
|
Klimova, Maria
|
Agranovich, Ilana
|
Martinov, Dmitry
|
Tuchin, Valery V.
|
Semyachkina-Glushkovskaya, Oxana V.
|
Kurths, Jürgen
|
Zinchenko, Ekaterina M.
Date: 2019
DOI: 10.1364/BOE.10.004003
Description: In this pilot study, we analyzed effects of transcranial photobiomodulation (tPBM, 1267 nm, 32 J/cm2) on clearance of beta-amyloid (Aβ) from the mouse brain. The immunohistochemical and confocal data clearly demonstrate the significant reduction of deposition of Aβ plaques in mice after tPBM vs. untreated animals. The behavior tests showed that tPBM improved the cognitive, memory and neurological status of mice with Alzheimer’s disease (AD). Using of our original method based on optical coherence tomography (OCT) analysis of clearance of gold nanorods (GNRs) from the brain, we proposed possible mechanism underlying tPBM-stimulating effects on clearance of Aβ via the lymphatic system of the brain and the neck. These results open breakthrough strategies for a non-pharmacological therapy of Alzheimer’s disease and clearly demonstrate that tPBM might be a promising therapeutic target for preventing or delaying Alzheimer’s disease.

Relationships: Show Relationship Browser for this Object
collection(s): Физический факультет | Научное управление
Identifier: смотреть в электронном каталоге НБ ТГУ
Type: статьи в журналах
Source: Biomedical optics express. 2019. Vol. 10, № 8. P. 4003-4017
Language: eng

Created: 10-01-2020

9372 Visitors

9137 Hits

550 Downloads

Научное управление

Физический факультет Pilot study of transcranial photobiomodulation of lymphatic clearance of beta-amyloid from the mouse brain: breakthrough strategies for non-pharmacologic therapy of Alzheimer's disease