An injectable nanocomposite hydrogel with deep penetration ability for enhanced photothermal and chemotherapy

doi:10.1016/j.jcis.2025.01.146

Эндаумент фонд ТГУ!
Впиши своё имя в историю университета
- Сделать пожертвование -

Add to "Quick Collection"

Description	Size	Format
An injectable nanocomposite hydrogel with deep penetration ability for enhanced photothermal and chemotherapy	12 MB	Adobe Acrobat PDF	Read	Download
DOI Доступ к ресурсу на сайте издателя			10.1016/j.jcis.2025.01.146

#полиэлектролитные гидрогели

#коллагеназа

#полианилин

#глубокое проникновение

#фототермическая терапия

#химиотерапия

Title: An injectable nanocomposite hydrogel with deep penetration ability for enhanced photothermal and chemotherapy
Creator: Chen, Yuru
|
Fan, Ziteng
|
Xu, Wenya
|
Zhu, Ziyi
|
Tan, Zhen
|
Hu, Yaqin
|
Kurzina, Irina A.
|
Cherdyntseva, Nadezhda V.
|
Yang, Wen Jing
|
Wang, Lianhui
Date: 2025
DOI: 10.1016/j.jcis.2025.01.146
Description: The excessive extracellular matrix (ECM) in solid tumors significantly inhibits the deep penetration and homogeneous distribution of nanodrugs, which greatly reduces the therapeutic efficacy. In the present work, an injectable polyelectrolyte hydrogel (CD@IPH) containing collagenase and doxorubicin-loaded polyacrylic acid@polyaniline nanoparticles (DOX@NP) were developed for improved photothermal and chemotherapy. The collagenase is released quickly from the polyelectrolyte hydrogel in the first 12 h, effectively degrading ECM and enhancing the deep penetration and evenly distribution of DOX@NP in tumor tissues. Then, the tumor microenvironment-triggered release of DOX from DOX@NP exhibits improved photothermal and chemotherapeutic efficiency. Owing to the excellent photoacoustic and photothermal properties of polyaniline inner cores of DOX@NP, the drug penetration process can be monitored to enable the image-guided cancer therapy. Both in vitro and in vivo assays prove the superior therapeutic efficacy of collagenase-enhanced photothermal and chemotherapy. The designed nanocomposite hydrogel therefore provides a versatile drug delivery system for deep tumor synergistic therapies.

Relationships: Show Relationship Browser for this Object
collection(s): Химический факультет
Identifier: смотреть в электронном каталоге НБ ТГУ
Relation: Journal of colloid and interface science
Type: статьи в журналах
Source: Journal of colloid and interface science. 2025. Vol. 685. P. 268-279
Language: eng

Created: 24-10-2025

93 Visitors

102 Hits

9 Downloads

Химический факультет An injectable nanocomposite hydrogel with deep penetration ability for enhanced photothermal and chemotherapy