Optical coherence microangiography of the mouse kidney for diagnosis of circulatory disorders

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Optical coherence microangiography of the mouse kidney for diagnosis of circulatory disorders	5 MB	Adobe Acrobat PDF	Read	Download
DOI Доступ к ресурсу на сайте издателя			10.1364/BOE.430393

Title: Optical coherence microangiography of the mouse kidney for diagnosis of circulatory disorders
Creator: Abdurashitov, Arkady S.
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Prikhozhdenko, Ekaterina S.
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Mayorova, Oksana A.
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Plastun, Valentina O.
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Gusliakova, Olga I.
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Shushunova, Natalia A.
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Kulikov, Oleg A.
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Tuchin, Valery V.
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Sukhorukov, Gleb B.
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Sindeeva, Olga A.
Date: 2021
DOI: 10.1364/BOE.430393
Description: Optical coherence tomography (OCT) has become widespread in clinical applications in which precise three-dimensional functional imaging of living organs is required. Nevertheless, the kidney is inaccessible for the high resolution OCT imaging due to a high light attenuation coefficient of skin and soft tissues that significantly limits the penetration depth of the probing laser beam. Here, we introduce a surgical protocol and fixation scheme that enables functional visualization of kidney’s peritubular capillaries via OCT microangiography. The model of reversible/irreversible glomerulus embolization using drug microcarriers confirms the ability of OCT to detect circulatory disorders. This approach can be used for choosing optimal carriers, their dosages and diagnosis of other blood flow pathologies.

Created: 14-12-2022

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Физический факультет Optical coherence microangiography of the mouse kidney for diagnosis of circulatory disorders