Enabling magnetic resonance imaging of hollow-core microstructured optical fibers via nanocomposite coating

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Enabling magnetic resonance imaging of hollow-core microstructured optical fibers via nanocomposite coating	1 MB	Adobe Acrobat PDF	Read	Download
DOI Доступ к ресурсу на сайте издателя			10.1364/OE.27.009868

Title: Enabling magnetic resonance imaging of hollow-core microstructured optical fibers via nanocomposite coating
Creator: Zanishevskaya, Anastasia A.
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Shuvalov, Andrey A.
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German, Sergei V.
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Inozemtseva, Olga A.
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Kochergin, Taras P.
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Lazareva, Ekaterina N.
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Tuchin, Valery V.
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Ginzburg, Pavel
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Skibina, Julia S.
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Noskov, Roman E.
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Gorin, Dmitry A.
Date: 2019
DOI: 10.1364/OE.27.009868
Description: Optical fibers are widely used in bioimaging systems as flexible endoscopes that are capable of low-invasive penetration inside hollow tissue cavities. Here, we report on the technique that allows magnetic resonance imaging (MRI) of hollow-core microstructured fibers (HC-MFs), which paves the way for combing MRI and optical bioimaging. Our approach is based on layer-by-layer assembly of oppositely charged polyelectrolytes and magnetite nanoparticles on the inner core surface of HC-MFs. Incorporation of magnetite nanoparticles into polyelectrolyte layers renders HC-MFs visible for MRI and induces the red-shift in their transmission spectra. Specifically, the transmission shifts up to 60 nm have been revealed for the several-layers composite coating, along with the high-quality contrast of HC-MFs in MRI scans. Our results shed light on marrying fiber-based endoscopy with MRI to open novel possibilities for minimally invasive clinical diagnostics and surgical procedures in vivo.

Created: 08-07-2019

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Научное управление Enabling magnetic resonance imaging of hollow-core microstructured optical fibers via nanocomposite coating