Neurohumoral markers that predict the efficiency of pharmacologic therapy of depressive disorders

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Neurohumoral markers that predict the efficiency of pharmacologic therapy of depressive disorders	109 KB	Adobe Acrobat PDF	Read	Download
DOI Доступ к ресурсу на сайте издателя			10.1134/S1819712417020088

Title: Neurohumoral markers that predict the efficiency of pharmacologic therapy of depressive disorders
Creator: Vyalova, N. M.
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Simutkin, G. G.
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Bokhan, N. A.
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Ivanova, S. A.
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Levchuk, L. A.
Date: 2017
DOI: 10.1134/S1819712417020088
Description: We present a comprehensive clinical and biological study of 46 patients with depressive disorder (F32-F33: depressive episode and recurrent depressive disorder) during pharmacotherapy. Neurohumoral factors (cortisol, brain-derived neurotrophic factor, serotonin, DHEA and its sulfated form) were determined in serum by ELISA. The severity of the current depressive episode was evaluated using the 17-point Hamilton Depression Rating Scale (HDRS-17); the pharmacotherapy efficacy was evaluated using the scale of the Clinical Global Impression (CGI Scale). We showed that before prescription of pharmacotherapy peripheral blood neurohumoral markers that characterize the state of stress-realizing and stress-limiting systems of the body may be considered as biological predictors of the effective pharmacotherapy of a current depressive episode and used as additional paraclinical examination methods. At higher concentrations of cortisol and serotonin associated with a decrease in the content of neurosteroid dehydroepiandrosterone, the high efficiency of the pharmacotherapy of depressive episode is predicted.

Created: 26-11-2018

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Факультет психологии Neurohumoral markers that predict the efficiency of pharmacologic therapy of depressive disorders