MRI study of the cuprizone-induced mouse model of multiple sclerosis: demyelination is not found after co-treatment with polyprenols (long-chain isoprenoid alcohols)

doi:10.1088/1742-6596/677/1/012007

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MRI study of the cuprizone-induced mouse model of multiple sclerosis: demyelination is not found after co-treatment with polyprenols (long-chain isoprenoid alcohols)	1 MB	Adobe Acrobat PDF	Read	Download
DOI Доступ к ресурсу на сайте издателя			10.1088/1742-6596/677/1/012007

#рассеянный склероз

#демиелинизация

#магнитно-резонансная визуализация

#купризоновая модель

Title: MRI study of the cuprizone-induced mouse model of multiple sclerosis: demyelination is not found after co-treatment with polyprenols (long-chain isoprenoid alcohols)
Creator: Khodanovich, Marina Yu.
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Pan, Edgar S.
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Akulov, Andrey E.
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Krutenkova, Elena P.
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Trusov, V.
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Yarnykh, Vasily L.
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Glazacheva, V.
Date: 2016
DOI: 10.1088/1742-6596/677/1/012007
Description: Multiple sclerosis is a neurological disorder with poorly understood pathogenic mechanisms and a lack of effective therapies. Therefore, the search for new MS treatments remains very important. This study was performed on a commonly used cuprizone animal model of multiple sclerosis. It evaluated the effect of a plant-derived substance called Ropren® (containing approximately 95% polyprenols or long-chain isoprenoid alcohols) on cuprizone- induced demyelination. The study was performed on 27 eight-week old male CD-1 mice. To induce demyelination mice were fed 0.5% cuprizone in the standard diet for 10 weeks. Ropren® was administered in one daily intraperitoneal injection (12mg/kg), beginning on the 6th week of the experiment. On the 11th week, the corpus callosum in the brain was evaluated in all animals using magnetic resonance imaging with an 11.7 T animal scanner using T2- weighted sequence. Cuprizone treatment successfully induced the model of demyelination with a significant decrease in the size of the corpus callosum compared with the control group (p<0.01). Mice treated with both cuprizone and Ropren® did not exhibit demyelination in the corpus callosum (p<0.01). This shows the positive effect of polyprenols on cuprizone-induced demyelination in mice.

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collection(s): НИИ биологии и биофизики | Институт биологии, экологии, почвоведения, сельского и лесного хозяйства (Биологический институт) | Научное управление
Identifier: смотреть в электронном каталоге НБ ТГУ
Type: статьи в журналах
Source: Journal of Physics: Conference Series. 2016. Vol. 677. P. 01200 (1-6)
Language: eng

Created: 12-04-2018

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НИИ биологии и биофизики

Институт биологии, экологии, почвоведения, сельского и лесного хозяйства (Биологический институт)

Научное управление MRI study of the cuprizone-induced mouse model of multiple sclerosis: demyelination is not found after co-treatment with polyprenols (long-chain isoprenoid alcohols)