Laser speckle contrast imaging of cerebral blood flow of newborn mice at optical clearing

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DOI Доступ к ресурсу на сайте издателя			10.1117/12.2268358

Title: Laser speckle contrast imaging of cerebral blood flow of newborn mice at optical clearing
Creator: Timoshina, Polina A.
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Tuchina, Daria K.
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Sagatova, Madina M.
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Semyachkina-Glushkovskaya, Oxana V.
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Tuchin, Valery V.
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Zinchenko, Ekaterina M.
Date: 2017
DOI: 10.1117/12.2268358
Description: In this work, we consider the use of optical clearing agents to improve imaging quality of the cerebral blood flow of newborn mice. Aqueous 60%-glycerol solution, aqueous 70%-OmnipaqueTM(300) solution and OmnipaqueTM (300) solution in water/DMSO(25%/5%) were selected as the optical clearing agents. Laser speckle contrast imaging (LSCI) was used for imaging of cerebral blood flow in newborn mice brain during topical optical clearing of tissuesin the area of the fontanelle. These results demonstrate the effectiveness of glycerol and Omnipaque solutions as optical clearing agents for investigation of cerebral blood flow in newborn mice without scalp removing and skull thinning.

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collection(s): Научное управление
Identifier: смотреть в электронном каталоге НБ ТГУ
Type: статьи в журналах
Source: Proceedings of SPIE. 2017. Vol. 10336 : Saratov Fall Meeting 2016 : Optical Technologies in Biophysics and Medicine XVIII, 27-30 September 2016, Saratov, Russian Federation. P. 1033610-1-1033610-7
Language: eng

Created: 18-01-2018

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Научное управление Laser speckle contrast imaging of cerebral blood flow of newborn mice at optical clearing