Effect of small and radical surgical injury on the level of different populations of circulating tumor cells in the blood of breast cancer patients

doi:10.4149/neo_2017_315

Эндаумент фонд ТГУ!
Впиши своё имя в историю университета
- Сделать пожертвование -

Add to "Quick Collection"

Description	Size	Format
Effect of small and radical surgical injury on the level of different populations of circulating tumor cells in the blood of breast cancer patients	1 MB	Adobe Acrobat PDF	Read	Download
DOI Доступ к ресурсу на сайте издателя			10.4149/neo_2017_315

#рак молочной железы

#циркулирующие опухолевые клетки

#раковые стволовые клетки

#эпителиально-мезенхимальный переход

#проточноя цитометрия

Title: Effect of small and radical surgical injury on the level of different populations of circulating tumor cells in the blood of breast cancer patients
Creator: Tarabanovskaya, Natalia A.
|
Staheeva, M. N.
|
Savelieva, Olga E.
|
Tashireva, Liubov A.
|
Denisov, Evgeny V.
|
Perelmuter, Vladimir M.
|
Kaigorodova, Evgeniya V.
Date: 2017
DOI: 10.4149/neo_2017_315
Description: Circulating tumor cells (CTCs) constitute a heterogeneous population. Some tumor cells are cancer stem cells (CSCs), while others are in the process of the epithelial-mesenchymal transition (EMT); however, most CTCs are neither stem cells nor in the EMT. This prospective study of 22 patients with nonspecific-type invasive carcinoma of the breast identified different populations of CTCs by flow cytometry in the blood of patients before biopsy, after biopsy and after surgical tumor removal without neoadjuvant chemotherapy. The results showed that minor surgical injury (biopsy) was accompanied by a significant increase in the blood levels of CTCs without signs of the EMT or stemness (Epcam+CD45-CD44-CD24-Ncadh-) and CTCs with signs of stemness and without signs of the EMT (Epcam+CD45-CD44+CD24-Ncadh-). Our results suggest that minor surgical injury to a tumor contributes to the release of CTCs into the bloodstream, including a population of stem cells.

Relationships: Show Relationship Browser for this Object
collection(s): Научное управление
Identifier: смотреть в электронном каталоге НБ ТГУ
Relation: Neoplasma
Type: статьи в журналах
Source: Neoplasma. 2017. Vol. 64, № 3. P. 437-443
Language: eng

Created: 25-10-2017

2901 Visitors

2545 Hits

416 Downloads

Научное управление Effect of small and radical surgical injury on the level of different populations of circulating tumor cells in the blood of breast cancer patients