Microarray study of single nucleotide polymorphisms and expression of ATP-binding cassette genes in breast tumors

Эндаумент фонд ТГУ!
Впиши своё имя в историю университета
- Сделать пожертвование -

Add to "Quick Collection"

Description	Size	Format
Microarray study of single nucleotide polymorphisms and expression of ATP-binding cassette genes in breast tumors	249 KB	Adobe Acrobat PDF	Read	Download
DOI Доступ к ресурсу на сайте издателя			10.1063/1.4936031

Title: Microarray study of single nucleotide polymorphisms and expression of ATP-binding cassette genes in breast tumors
Creator: Tsyganov, Matvey M.
|
Karabut, I. V.
|
Freydin, M. B.
|
Choinzonov, Evgeny L.
|
Litvyakov, Nicolay V.
|
Ibragimova, Marina K.
Date: 2015
DOI: 10.1063/1.4936031
Description: Our previous research establishes that changes of expression of the ATP-binding cassette genes family is connected with the neoadjuvant chemotherapy effect. However, the mechanism of regulation of resistance gene expression remains unclear. As many researchers believe, single nucleotide polymorphisms can be involved in this process. Thereupon, microarray analysis is used to study polymorphisms in ATP-binding cassette genes. It is thus found that MDR gene expression is connected with 5 polymorphisms, i.e. rs241432, rs241429, rs241430, rs3784867, rs59409230, which participate in the regulation of expression of own genes.