Obtaining of biodegradable polylactide films and fibers filled hydroxyapatite for medical purposes

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Obtaining of biodegradable polylactide films and fibers filled hydroxyapatite for medical purposes	857 KB	Adobe Acrobat PDF	Read	Download
DOI Доступ к ресурсу на сайте издателя			10.1063/1.4936055

Title: Obtaining of biodegradable polylactide films and fibers filled hydroxyapatite for medical purposes
Creator: Lytkina, Darya N.
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Rasskazova, Lyudmila A.
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Kurzina, Irina A.
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Filimoshkin, Anatoliy G.
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Shapovalova, Yelena G.
Date: 2015
DOI: 10.1063/1.4936055
Description: Relevance of the work is due to the need for new materials that are used in medicine (orthopedics, surgery, dentistry, and others) as a substitute for natural bone tissue injuries, fractures, etc. The aim of presented work is developing of a method of producing biocompatible materials based on polyesters of hydroxycarboxylic acids and calcium phosphate ceramic (hydroxyapatite, HA) with homogeneous distribution of the inorganic component. Bioactive composites based on poly-L-lactide (PL) and hydroxyapatite with homogeneous distribution were prepared. The results of scanning electron microscopy confirm homogeneous distribution of the inorganic filler in the polymer matrix. The positive effect of ultrasound on the homogeneity of the composites was determined. The rate of hydrolysis of composites was evaluated. The rate of hydrolysis of polylactide as an individual substance is 7 times lower than the rate of hydrolysis of the polylactide as a part of the composite. It was found that materials submarines HA composite and do not cause a negative response in the cells of the immune system, while contributing to anti-inflammatory cytokines released by cells.