The role of cAMP- and IKK-2-dependent pathways in stimulation of the growth capacity of mesenchymal progenitor cells with alkaloid songorine was studied in vitro. Inhibitors of adenylate cyclase and IKK-2 were shown to abolish the increase in proliferative activity of progenitor cells. Moreover, blockade of the inhibitory kinase complex was accompanied by a decrease in the intensity of progenitor cell differentiation.
Физический факультет
Role of cAMP- and IKK-2-dependent signaling pathways in functional stimulation of mesenchymal progenitor cells with alkaloid songorine
2551 Visitors
2567 Hits
4 Downloads
