Circulating microRNAs in lung cancer: prospects for diagnosis, prognosis, and prediction of antitumor treatment efficacy

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Description	Size	Format
Circulating micrornas in lung cancer: prospects for diagnosis, prognosis, and prediction of antitumor treatment efficacy	182 KB	Adobe Acrobat PDF	Read	Download
DOI Доступ к ресурсу на сайте издателя			10.1134/S0026893315010161

Title: Circulating microRNAs in lung cancer: prospects for diagnosis, prognosis, and prediction of antitumor treatment efficacy
Creator: Vlassov, V. V.
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Ponomaryova, A. A.
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Zaporozhchenko, I. A.
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Morozkin, E. S.
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Cherdyntseva, Nadezhda V.
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Laktionov, P. P.
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Rykova, E. Yu.
Date: 2015
DOI: 10.1134/S0026893315010161
Description: The review considers the main techniques to extract microRNA (miRNA) from various biological fluids (in particular, the serum and plasma), approaches to the analysis of miRNA concentration and composition, and methods to normalize the results in data analyses. Advantages and drawbacks of the methods are described. Special attention is given to circulating miRNAs, which can be used as markers for minimally invasive diagnosis, prediction of antitumor treatment efficacy, and disease prognosis in lung cancer. The review discusses the prospects and limitations that arise as the clinical significance is evaluated for miRNAs as potential tumor markers and a better understanding is gained for the roles various miRNAs play in the pathogenesis of lung cancer.