Visualization of brain tumors with infrared-labeled aptamers for fluorescence-guided surgery

doi:10.1021/jacs.4c06716

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Visualization of brain tumors with infrared-labeled aptamers for fluorescence-guided surgery	3 MB	Adobe Acrobat PDF	Read	Download
DOI Доступ к ресурсу на сайте издателя			10.1021/jacs.4c06716

#визуализация опухолей головного мозга

#аптамеры

#флуоресценция

Title: Visualization of brain tumors with infrared-labeled aptamers for fluorescence-guided surgery
Creator: Zamay, Galina S.
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Koshmanova, Anastasia A.
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Narodov, Andrey A.
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Gorbushin, Anton
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Voronkovskii, Ivan
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Grek, Daniil
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Luzan, Natalia A.
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Kolovskaya, Olga S.
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Shchugoreva, Irina A.
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Artyushenko, Polina V.
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Glazyrin, Yury E.
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Fedotovskaya, Victoriya D.
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Kuziakova, Olga N.
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Veprintsev, Dmitry V.
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Belugin, Kirill
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Lapin, Ivan N.
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Svetlichnyi, Valerii A.
Date: 2024
DOI: 10.1021/jacs.4c06716
Description: Gliomas remain challenging brain tumors to treat due to their infiltrative nature. Accurately identifying tumor boundaries during surgery is crucial for successful resection. This study introduces an innovative intraoperative visualization method utilizing surgical fluorescence microscopy to precisely locate tumor cell dissemination. Here, the focus is on the development of a novel contrasting agent (IR-Glint) for intraoperative visualization of human glial tumors comprising infrared-labeled Glint aptamers. The specificity of IR-Glint is assessed using flow cytometry and microscopy on primary cell cultures. In vivo effectiveness is studied on mouse and rabbit models, employing orthotopic xenotransplantation of human brain gliomas with various imaging techniques, including PET/CT, in vivo fluorescence visualization, confocal laser scanning, and surgical microscopy. The experiments validate the potential of IR-Glint for the intraoperative visualization of gliomas using infrared imaging. IR-Glint penetrates the blood−brain barrier and can be used for both intravenous and surface applications, allowing clear visualization of the tumor. The surface application directly to the brain reduces the dosage required and mitigates potential toxic effects on the patient. The research shows the potential of infrared dye labeled aptamers for accurately visualizing glial tumors during brain surgery. This novel aptamer-assisted fluorescence-guided surgery (AptaFGS) may pave the way for future advancements in the field of neurosurgery.

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collection(s): Сибирский физико-технический институт
Identifier: смотреть в электронном каталоге НБ ТГУ
Relation: Journal of the American Chemical Society
Rights: Resource access is available in the premises of Research Library
Type: статьи в журналах
Source: Journal of the American Chemical Society. 2024. Vol. 146, № 36. P. 24989-25004
Language: eng

Created: 24-06-2025

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Сибирский физико-технический институт Visualization of brain tumors with infrared-labeled aptamers for fluorescence-guided surgery