The results of studying the microstructure and mechanical properties of the V-W-Cr alloy after different regimes of thermomechanical treatment are presented. It is shown that the use of the modified regime promotes the formation of a more uniform grain structure, which provides an increase in strength properties at room temperature by more than 10%. Analysis and comparison of the results showed that the thermal stability and the level of strength properties of V-Me(Cr, W)-Zr(C, O, N)-system alloys are mainly provided by the effects of disperse strengthening with stable Zr-based particles.