In vivo quantification of the effectiveness of topical low-dose photodynamic therapy in wound healing using two-photon microscopy

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In vivo quantification of the effectiveness of topical low-dose photodynamic therapy in wound healing using two-photon microscopy	83 MB	Adobe Acrobat PDF	Read	Download
DOI Доступ к ресурсу на сайте издателя			10.3390/pharmaceutics14020287

Title: In vivo quantification of the effectiveness of topical low-dose photodynamic therapy in wound healing using two-photon microscopy
Creator: Zuhayri, Hala
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Nikolaev, Viktor V.
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Knyazkova, Anastasia I.
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Lepekhina, Tatiana B.
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Krivova, Natalya A.
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Tuchin, Valery V.
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Kistenev, Yury V.
Date: 2022
DOI: 10.3390/pharmaceutics14020287
Description: The effect of low-dose photodynamic therapy on in vivo wound healing with topical application of 5-aminolevulinic acid and methylene blue was investigated using an animal model for two laser radiation doses (1 and 4 J/cm2). A second-harmonic-generation-to-auto-fluorescence aging index of the dermis (SAAID) was analyzed by two-photon microscopy. SAAID measured at 60–80 μm depths was shown to be a suitable quantitative parameter to monitor wound healing. A comparison of SAAID in healthy and wound tissues during phototherapy showed that both light doses were effective for wound healing; however, healing was better at a dose of 4 J/cm2.