Diagnosis of glioma molecular markers by terahertz technologies

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Diagnosis of glioma molecular markers by terahertz technologies	8 MB	Adobe Acrobat PDF	Read	Download
DOI Доступ к ресурсу на сайте издателя			10.3390/photonics8010022

Title: Diagnosis of glioma molecular markers by terahertz technologies
Creator: Cherkasova, Olga P.
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Peng, Yan
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Konnikova, Maria R.
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Kistenev, Yury V.
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Shi, Chenjun
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Vrazhnov, Denis A.
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Shevelev, Oleg B.
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Zavjalov, Evgenii L.
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Kuznetsov, Sergei
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Shkurinov, Alexander P.
Date: 2021
DOI: 10.3390/photonics8010022
Description: This review considers glioma molecular markers in brain tissues and body fluids, shows the pathways of their formation, and describes traditional methods of analysis. The most important optical properties of glioma markers in the terahertz (THz) frequency range are also presented. New metamaterial-based technologies for molecular marker detection at THz frequencies are discussed. A variety of machine learning methods, which allow the marker detection sensitivity and differentiation of healthy and tumor tissues to be improved with the aid of THz tools, are considered. The actual results on the application of THz techniques in the intraoperative diagnosis of brain gliomas are shown. THz technologies’ potential in molecular marker detection and defining the boundaries of the glioma’s tissue is discussed.