Premalignant changes in the bronchial epithelium are prognostic factors of distant metastasis in non-small cell lung cancer patients

doi:10.3389/fonc.2021.771802

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Premalignant changes in the bronchial epithelium are prognostic factors of distant metastasis in non-small cell lung cancer patients	14 MB	Adobe Acrobat PDF	Read	Download
DOI Доступ к ресурсу на сайте издателя			10.3389/fonc.2021.771802

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#поражение бронхов

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Title: Premalignant changes in the bronchial epithelium are prognostic factors of distant metastasis in non-small cell lung cancer patients
Creator: Pankova, Olga V.
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Tashireva, Liubov A.
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Rodionov, Evgeniy O.
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Miller, Sergey V.
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Tuzikov, Sergey A.
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Pismenny, Dmitry S.
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Gerashchenko, Tatiana S.
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Zavyalova, Marina V.
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Vtorushin, Sergey V.
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Denisov, Evgeny V.
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Perelmuter, Vladimir M.
Date: 2021
DOI: 10.3389/fonc.2021.771802
Description: Background: The study assessed the possibility of dividing patients into groups based on the assessment of morphological changes in the epithelium of small-caliber bronchi located near the primary tumor in order to predict high and low risks of distant metastasis of non-small cell lung cancer. Methods: In 171 patients with non-small cell lung cancer (T1-4N0-3M0) in small-caliber bronchi taken at a distance of 3–5 cm from the tumor, various variants of morphological changes in the bronchial epithelium (basal cell hyperplasia (BCH), squamous cell metaplasia (SM), and dysplasia (D)) were assessed. Long-term results of treatment, namely, distant metastasis, were assessed after 2 and 5 years. Results: During the follow-up period, distant metastases were found in 35.1% (60/171) of patients. Most often, they were observed in patients of the high-risk group: BCH+SM−D−(51.6%, 40/95) and BCH−SM+D+ (54.4%, 6/11). Less often, distant metastases were observed in low-risk group patients: BCH+SM+D− (6.7%, 3/45) and BCH−SM−D−(10.0%, 2/20). Tumor size, grade, and stage were significant predictors of metastasis only in the high-risk group. The 5-year metastasis-free survival was better in the low-risk group of distant metastases. Conclusions: Isolated BCH or dysplasia in small bronchi distant from foci of tumor isassociated with a high-risk distant metastasis and less 5-year metastasis-free survival.

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collection(s): Химический факультет
Identifier: смотреть в электронном каталоге НБ ТГУ
Type: статьи в журналах
Source: Frontiers in oncology. 2021. Vol. 11. P. 771802 (1-10)
Language: eng

Created: 14-06-2022

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Химический факультет Premalignant changes in the bronchial epithelium are prognostic factors of distant metastasis in non-small cell lung cancer patients