It is known that morphological changes in the bronchial epithelium at a distance from the tumor focus in patients with NSCLC may predispose to a certain clinical course of the disease. Thus, the combination of basal cell hyperplasia and squamous metaplasia is a predictor of local recurrence. However, the reasons for this connection are still unclear. The aim of this study was to identify the mutational landscape of NSCLC in patients at high risk of relapse. The study included 12 patients with NSCLC of stage T1-4N0-3M0, divided into two groups depending on the presence of morphological changes in the type of combined basal cell hyperplasia and squamous metaplasia. Exomic DNA libraries of patients were sequenced to assess the mutational landscape. As a result, it was found that patients with the presence of combined changes and persons without it differ from each other in the number and spectrum of genetic disorders.
Перспективы развития фундаментальных наук : сборник научных трудов XVIII Международной конференции студентов, аспирантов и молодых ученых, 27–30 апреля 2021 г.. Томск, 2021. Т. 4 : Биология и фундаментальная медицина. С. 97-99