Functional and morphological changes in the mother-placenta-fetus system during chronic hypoxia (experimental study)

doi:10.1117/12.2523634

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DOI Доступ к ресурсу на сайте издателя			10.1117/12.2523634

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Title: Functional and morphological changes in the mother-placenta-fetus system during chronic hypoxia (experimental study)
Creator: Palatova, Tatiana V.
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Maslyakova, Galina N.
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Chekhonatskaya, Marina L.
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Bucharskaya, Alla B.
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Genina, Elina A.
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Bashkatov, Alexey N.
Date: 2019
DOI: 10.1117/12.2523634
Description: The aim of work was to study the characteristics of uteroplacental blood flow in pregnant rats, tissue oxygenation and the morphological features of the main internal organs (heart, liver, kidneys) of newborns during chronic intrauterine hypoxia. The rats (8 animals) were divided into 2 experimental groups. The first (hypoxia) group was subjected to hypoxia throughout pregnancy (21 days). The second (control) group was not exposed to any effect throughout the pregnancy. On the 20th day of gestation in both groups, a Doppler ultrasound study of uterine-fetal blood flow and measurement of the placenta was performed. Newborn rat pups of the first day of life were subjected to oxygenation degree measurement. After delivery, the number of rats in the litter was counted and their body weight was measured. After the measurements the laboratory animals were withdrawn from the experiments and morphological study of their internal organs was performed. The studies have shown a clear relationship between the characteristics of uterine blood flow and the presence or absence of hypoxia. In chronic hypoxia, there were low rates of arterial blood flow, an increase in the peripheral resistance of uterine vessels. All this indicates the defective formation of the placenta and impaired blood flow with the development of placental insufficiency. It was also found that hypoxia in the antenatal period adversely affects the number and somatometric indicators of newborn rats in the offspring. Histological examination of the tissues of the heart, liver and kidney of newborn rat pups showed signs of impaired blood circulation, dystrophic and necrobiotic changes in the parenchyma.

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collection(s): Научное управление
Identifier: смотреть в электронном каталоге НБ ТГУ
Type: статьи в журналах
Source: Proceedings of SPIE. 2019. Vol. 11065 : Saratov fall meeting 2018 : Optical and nano-technologies for biology and medicine. P. 110651W-1-110651W-8
Language: eng