In this study, we assessed the mutational landscape of lung squamous carcinoma (LUSC) in patients with isolated basal cell hyperplasia (BCH) in the bronchial epithelium at a distance from the primary tumor who are at high risk of distant metastasis. Three patient groups have been involved in the study: 1) Patients with isolated BCH and metastases; 2) Patients with isolated BCH but without metastases; 3) Patients without premalignant bronchial lesions and metastases. A highly mutable phenotype was found only in patients with isolated BCH and distant metastases. Also, these patients more frequently harbored mutations in genes that encode regulators of cell adhesion and actin cytoskeleton.
Перспективы развития фундаментальных наук : сборник научных трудов XVIII Международной конференции студентов, аспирантов и молодых ученых, 27–30 апреля 2021 г.. Томск, 2021. Т. 4 : Биология и фундаментальная медицина. С. 103-105