3D‑printed biodegradable composite poly(lactic acid)‑based scaffolds with a shape memory effect for bone tissue engineering

doi:10.1007/s42114-024-01084-1

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3D‑printed biodegradable composite poly(lactic acid)‑based scaffolds with a shape memory effect for bone tissue engineering	2 MB	Adobe Acrobat PDF	Read	Download
DOI Доступ к ресурсу на сайте издателя			10.1007/s42114-024-01084-1

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Title: 3D‑printed biodegradable composite poly(lactic acid)‑based scaffolds with a shape memory effect for bone tissue engineering
Creator: Firoz, Abdullah bin
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Rybakov, Vladimir
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Fetisova, Anastasia A.
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Shlapakova, Lada E.
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Pariy, Igor O.
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Toropkov, Nikita E.
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Lozhkomoev, Aleksandr S.
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Mukhortova, Yulia R.
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Sharonova, Anna A.
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Wagner, Dmitriy V.
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Surmeneva, Maria A.
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Kholkin, Andrei L.
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Surmenev, Roman A.
Date: 2025
DOI: 10.1007/s42114-024-01084-1
Description: In this study, 3D-printed biodegradable poly(lactic acid) (PLA) and hybrid PLA scaffolds doped with magnetite nanoparticles (PLA/Fe3O4) and having gyroid structure were investigated at various infill densities (100%, 70%, 50%, or 30%). Effects of infill density on the composition, structure, and mechanical properties (Young’s modulus, compression, and tensile strength) of the scaffolds and a shape memory effect were documented. Raman spectroscopy was used to detect the characteristic molecular bonds of PLA and magnetite. X-ray diffraction confirmed higher crystallinity of the materials printed with Fe3O4 addition. PLA/Fe3O4 composites showed ferrimagnetic behavior. Mechanical properties of PLA/Fe3O4 composite scaffolds with 50% porosity fall within the range of corresponding mechanical properties of native cancellous bone, and therefore these scaffolds hold promise for the repair of bone defects. Additionally, 3D-printed materials’ various sizes and shapes were tested to achieve shape recovery up to 85% for composite porous scaffolds with gyroid structure and up to 100% for nonporous pure PLA ribbons (the supporting walls). Furthermore, a decrease in the infill density of the gyroid scaffolds resulted in a higher shape recovery rate. A proposed mechanism of the shape memory effect in the printed scaffolds was also discussed. These findings suggest that the developed 3D-printed PLA/Fe3O4 scaffolds, with tunable mechanical properties and shape memory capabilities, offer significant potential for advanced biomedical applications, including personalized bone repair and regeneration.