https://vital.lib.tsu.ru/vital/access/manager/Index ${session.getAttribute("locale")} 5 https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000629818 Wed 27 Jun 2018 09:40:13 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000672252 Wed 25 Dec 2019 13:20:37 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001001523 Wed 10 May 2023 15:51:33 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001000863 -3.0 or <= -3.0 mL/min/1.73 m(2)/year, respectively. Fifty-five urinary metabolites and ratios were quantified, and the significant ones were selected. Logistic regression was used to determine prognostic performance in identifying those with a fast progressive course using baseline urine samples. Repeated-measures ANOVA was used to analyze whether changes in urinary metabolites over a 3-year follow-up period differed between fast and slow progressors. Results: In a single urinary sample, the prognostic performance of urinary metabolites was comparable to that of a model including height-adjusted total kidney volume (htTKV, AUC = 0.67). Combined with htTKV, the predictive value of the metabolite model increased (AUC = 0.75). Longitudinal analyses showed an increase in the myoinositol/citrate ratio (p < 0.001) in fast progressors, while no significant change was found in those with slow progression, which is in-line with an overall increase in the myoinositol/citrate ratio as GFR declines. Conclusion: A metabolic profile, measured at a single time point, showed at least equivalent prognostic performance to an imaging-based risk marker in ADPKD. Changes in urinary metabolites over a 3-year follow-up period were associated with a fast progressive disease course.]]> Wed 10 May 2023 10:12:38 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000644368 Wed 05 Dec 2018 12:28:44 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/koha:000896012 Thu 16 Jun 2022 13:20:50 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000535261 Mon 10 Dec 2018 12:44:08 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/koha:000998290 Fri 24 Mar 2023 10:53:30 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/koha:000899436 Fri 23 Sep 2022 09:27:52 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000437536 Fri 22 Sep 2017 12:37:10 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000794897 Fri 12 Mar 2021 14:13:37 KRAT ]]> https://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000635446 Fri 02 Nov 2018 11:01:55 KRAT ]]>