The isotopic substitution relations for the effective dipole moment parameters of a heterogenic diatomic molecule have been derived. These equations are applied to the calculations of the line intensities of the minor carbon monoxide isotopologues, including the radioactive ones. The comparisons of the calculated line intensities of the minor isotopologues to those observed and to those earlier calculated are given. These comparisons show that the used method has potential of predicting intensities of the minor isotopologues of carbon monoxide within 2–10%. The comparison of our calculated line intensities for the radioactive isotopologues of the carbon monoxide molecule to those from Li et al. (2015) is also given.